3549. Elliptinium Acetate

Nomenclature

CAS number: 58337-35-2
9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium acetate (salt); 9-hydroxy-2-methylellipticinium acetate; HME; NSC-264137; Celiptium (Sanofi-Aventis).
C20H20N2O3; mol wt 336.38.
C 71.41%, H 5.99%, N 8.33%, O 14.27%.

Description and references

Deriv of ellipticine, q.v., with anticancer activity. Prepn: J. LePecq et al., DE 2618223; J. B. LePecq, C. Paoletti, US 4310667 (1976, 1982 both to Agence Nat. Valorisation Recher.). Activity vs L 1210 mouse leukemia: eidem, C. R. Seances Acad. Sci. Ser. D 281, 1365 (1975). HPLC determn: G. Muzard, J. B. LePecq, J. Chromatogr. 169, 446 (1979). Metabolism, disposition: N. Van-Bac et al., Cancer Treat. Rep. 64, 879 (1980). Antitumor activity, pharmacology, toxicity study: C. Paoletti et al., Recent Results Cancer Res. 74, 107 (1980). Use in treatment of breast cancers: J. Rouesse et al., Bull. Cancer 68, 437 (1981). Cytochemical and autoradiographic study: N. Sales, E. Puvion, Eur. J. Cancer Clin. Oncol. 18, 291 (1982).

Chemical structure

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkaloids/Natural Products