3556. Embramine

Nomenclature

CAS number: 3565-72-8
2-[1-(4-Bromophenyl)-1-phenylethoxy]-N,N-dimethylethanamine; 2-[(p-bromo-α-methyl-α-phenylbenzyl)oxy]-N,N-dimethylethylamine; [2-(1-p-bromophenyl-1-phenylethoxy)ethyl]dimethylamine; 2-[1-(4-bromodiphenyl)ethoxy]-N,N-dimethylethylamine; p-bromo-α-methylbenzhydryl 2-dimethylaminoethyl ether; 1-(p-bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane; β-dimethylaminoethyl p-bromo-α-methylbenzhydryl ether.
C18H22BrNO; mol wt 348.28.
C 62.07%, H 6.37%, Br 22.94%, N 4.02%, O 4.59%.

Description and references

Prepn: L. Novak, M. Protiva, Collect. Czech. Chem. Commun. 24, 3966 (1959); M. Protiva, L. Novak, DE 1240877 (1967 to SPOFA), C.A. 67, 73338j (1967).

Chemical structure

Properties

bp0.3 135-140°. bp1 163-170°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 13977-28-1
Mebrophenhydramine; Bromadryl (Spofa); Mebryl.
C18H22BrNO.HCl; mol wt 384.74.
C 56.19%, H 6.03%, Br 20.77%, N 3.64%, O 4.16%, Cl 9.21%.

Properties

Crystals from acetone + ether, mp 150-152°. LD50 in mice (mg/kg): 80 i.v.; 330 orally (Protiva, Novak).

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Aminoalkylethers