Nomenclature
CAS number: 106-89-8
Chloromethyloxirane;
dl-α-epichlorohydrin; 1-chloro-2,3-epoxypropane; γ-chloropropylene oxide.
C
3H
5ClO; mol wt 92.52.
C 38.95%, H 5.45%, Cl 38.32%, O 17.29%.
Description and references
Prepn: H. T. Clarke, W. W. Hartman, Org. Synth. coll. vol. I, 233
(2nd ed., 1941); G. Braun, ibid. coll. vol. II, 256 (1943). Manuf: Faith, Keyes &
Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran,
Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 335-338. Toxicity
data: H. F. Smyth, C. P. Carpenter, J. Ind.
Hyg. Toxicol. 30, 63 (1948).
Properties
Liquid. d420 1.1812; d425 1.1750; d450 1.1436; d475 1.1101. bp760 117.9°; bp400 98.0°; bp200 79.3°; bp100 62.0°; bp40 42.0°; bp10 16.6°; bp1.0 -16.5°. mp -25.6°. nD11.6 1.44195; nD16 1.43969; nD25 1.43585. Flash pt, open cup: 105°F (40°C). Poisonous, flammable. Insol in water. Misc
with alcohol, ether, chloroform, trichloroethylene, carbon tetrachloride.
Immiscible with petr hydrocarbons. LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter).Caution
Potential symptoms of overexposure
are nausea, vomiting; abdominal pain; respiratory distress, coughing;
cyanosis; irritation of eyes and skin with deep pain; reproductive
effects. See NIOSH Pocket Guide
to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 128. See also Patty's Industrial Hygiene
and Toxicology vol. 2A, G. D. Clayton, F. E.
Clayton, Eds. (Wiley-Interscience, New York, 3rd ed., 1981) pp 2242-2247.
This substance is reasonably anticipated to be a human carcinogen:
Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-113.Use
Solvent for natural and synthetic resins, gums,
cellulose esters and ethers, paints, varnishes, nail enamels and lacquers,
cement for Celluloid. As stabilizer.