Humanized monoclonal antibody directed against CD22, a transmembrane sialoglycoprotein expressed on the surface of B-cell malignancies. Prepn: S.-O. Leung, H. Hansen, WO 9604925; eidem, US 5789554 (1996, 1998 both to Immunomedics); idem et al., Mol. Immunol. 32, 1413 (1995). Characterization and binding study: J. Carnahan et al., Clin. Cancer Res. 9, Suppl., 3982s (2003). Clinical pharmacokinetics and evaluation in non-Hodgkin's lymphoma: J. P. Leonard et al., Clin. Cancer Res. 10, 5327 (2004). Review of clinical development: A. B. Siegel et al., Semin. Oncol. 30, 457-464 (2003).
Prepn and biodistribution studies: S. V. Govindan et al, Bioconjugate Chem. 9, 773 (1998); G. L. Griffiths et al., J. Nucl. Med. 44, 77 (2003). Clinical pharmacokinetics and efficacy: R. M. Sharkey et al., ibid. 2000. Clinical evaluation in non-Hodgkin's lymphoma: O. Lindén et al., Clin. Cancer Res. 11, 5215 (2005).
Antineoplastic. 90Y-labeled form in radioimmunotherapy.
Antineoplastic; Monoclonal Antibodies
Epratuzumab Tetraxetan 90Y : Antineoplastic (Radiation Source)