3714. Etaqualone

Nomenclature

CAS number: 7432-25-9
3-(2-Ethylphenyl)-2-methyl-4(3H)-quinazolinone; 2-methyl-3-(o-ethylphenyl)-4-quinazolone; ethinazone; Aolan (Beiersdorf).
C17H16N2O; mol wt 264.32.
C 77.25%, H 6.10%, N 10.60%, O 6.05%.

Description and references

Prepd by condensation of N-acetylanthranilic acid and 2-ethylaniline with POCl3: BE 615282 (1962 to P. Beiersdorf AG), C.A. 58, 13971ef (1963). Structure-activity studies: Parmar et al., J. Med. Chem. 12, 138 (1969).

Chemical structure

Properties

mp 81°.

Derivative

Hydrochloride.
C17H16N2O.HCl; mol wt 300.78.
C 67.88%, H 5.70%, N 9.31%, O 5.32%, Cl 11.79%.

Properties

mp 247°.

Therapeutic Category

Sedative, hypnotic.

Keywords

Sedative/Hypnotic; Quinazolone Derivatives