3788. Ethyl Dibunate

Nomenclature

CAS number: 5560-69-0
3,6-Bis(1,1-dimethylethyl)-1-naphthalenesulfonic acid ethyl ester; 3,6-di-tert-butyl-1-naphthalenesulfonic acid ethyl ester; ethyl 3,6-di-tert-butyl-1-naphthalenesulfonate; 2,7-di-tert-butylnaphthalene-4-sulfonic acid ethyl ester; ethyl 2,7-di-tert-butylnaphthalene-4-sulfonate; dibunate ethyl; NDR-304; Neodyne.
C20H28O3S; mol wt 348.50.
C 68.93%, H 8.10%, O 13.77%, S 9.20%.

Description and references

Prepn: Menard et al., Can. J. Chem. 39, 729 (1961). Pharmacology: Shemano, Arch. Int. Pharmacodyn. Ther. 165, 410 (1967). Clinical trial in chronic cough: H. Sevelius, J. P. Colmore, Clin. Pharmacol. Ther. 8, 381 (1967).

Chemical structure

Properties

Crystals from ethanol, mp 138-139°.

Therapeutic Category

Antitussive.

Keywords

Antitussive