3831. Ethyl Nitrite

Nomenclature

CAS number: 109-95-5
Nitrous acid ethyl ester; nitrous ether.
C2H5NO2; mol wt 75.07.
C 32.00%, H 6.71%, N 18.66%, O 42.63%.
C2H5ONO.

Description and references

Prepd by the action of sodium nitrite on a mixture of alcohol and H2SO4 in the cold. The article of commerce contains 90-95% ethyl nitrite, the remainder is chiefly alcohol as preservative. Laboratory generation of ethyl nitrite gas by placing 20 liters of 90% ethanol in a suitable vessel, diluting with 200 liters of water, and while stirring, adding to the dil alc 18.3 kg of nitrosyl chloride at the rate of 2.25 kg per hour; see also Chase, US 2615896 (1952).

Properties

Colorless or yellowish, clear, exceedingly volatile liq. Characteristic odor; burning, sweetish taste. d1515 0.90. bp 17°. Slightly sol in water and dec by it; miscible with alcohol, ether. On keeping, it gradually dec, becoming acid and oxides of nitrogen form. Decompn is hastened by air, light, and moisture. Flammable, poisonous. Keep tightly closed, in a cool place, protected from light.

Derivative

Spirit of Ethyl Nitrite.

Nomenclature

Spirit of nitrous ether; sweet spirit of niter.

Description and references

An alcoholic soln containing 3.5-4.5% ethyl nitrite.

Properties

Pale yellow or faintly greenish-yellow, clear, mobile, volatile, flammable liquid; ethereal, pungent odor; sharp, burning taste. The ethyl nitrite evaporates rapidly; dec on exposure to air; dec in light. d25 ≤0.823. Miscible with water and alcohol. Flammable, poisonous. Keep tightly closed, protected from light, in a cool place, remote from fire.

Caution

May cause methemoglobinemia and hypotension and, in high concns, narcosis.

Therapeutic Category

Has been used as diaphoretic.