3893. Etrimfos

Nomenclature

CAS number: 38260-54-7
Phosphorothioic acid O-(6-ethoxy-2-ethyl-4-pyrimidinyl) O,O-dimethyl ester; O,O-dimethyl O-(2-ethyl-4-ethoxypyrimidinyl)-6-thionophosphate; SAN-197; Ekamet (Sandoz); Satisfar (Sandoz).
C10H17N2O4PS; mol wt 292.29.
C 41.09%, H 5.86%, N 9.58%, O 21.90%, P 10.60%, S 10.97%.

Description and references

Organophosphate insecticide; cholinesterase inhibitor. Prepn: K. Milzner, F. Reisser, DE 2209554; eidem, US 3862188 (1972, 1975 both to Sandoz). Physical properties and activity: H. J. Knutti, F. Reisser, Proc. 8th Br. Insectic. Fungic. Conf. 2, 675 (1975). Residue analysis and toxicity study: M. C. Bowman et al., J. Agric. Food Chem. 26, 35 (1978) DOI PubMed. Metabolism in plants: M. Akram et al., ibid. 925 DOI. Field studies of formulations: D. A. Collins, D. A. Cook, Crop Prot. 17, 521 (1998) DOI. Review of analytical methods: J. C. Karapally et al., Anal. Methods Pestic. Plant Growth Regul. 11, 125-138 (1980).

Chemical structure

Properties

Colorless oil, slight characteristic odor. mp -3.35°. d 1.195; nD20 1.5068. Vapor pressure at 20°: 6.5 × 10-5 mm Hg. Soly in water at 23-24°: 40 ppm. Miscible with ethanol, dimethyl sulfoxide, ethyl acetate, acetone, ether, chloroform, xylene, hexane. LD50 in male rats, mice (mg/kg): 1800, 437 orally; LC50 in carp (mg/l): 13.6 (48 hr); 13.3 (96 hr) (Knutti).

Use

Agricultural insecticide.