Description and references

A plasma and serum glycoprotein that participates in the middle phases of blood coagulation. Activated by factor XI and Ca²⁺. Interacts then with factor VIII, Ca²⁺, and phospholipid to form the complex which converts factor X into factor X_a. Isoln and characterization of bovine factor IX: K. Fujikawa et al., Biochemistry 12, 4938 (1973); K. Fujikawa, E. W. Davie, Methods Enzymol. 45B, 74 (1976). Deficiency results in a congenital bleeding disorder known as Christmas disease or hemophilia B. Review: Macfarlane in Thrombolytic Activity and Related Phenomena, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1961) pp 408-415; B. N. Bouma, J. A. Van Mourik, Haemostasis: Biochemistry, Physiology & Pathology, D. Ogston, B. Bennett, Eds. (Wiley-Interscience, New York, 1977) pp 56-77.

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