3963. Fenbufen
Nomenclature
CAS number: 36330-85-5
γ-Oxo-[1,1′-biphenyl]-4-butanoic acid; 3-(4-biphenylylcarbonyl)propionic acid; β-p-phenylbenzoylpropionic acid; diphenyl-4-γ-oxo-γ-butyric acid; 4-(4-biphenylyl)-4-oxobutyric acid; CL-82204; Bufemid (Lederle); Cinopal (Lederle); Cinopol (Lederle); Lederfen (Am. Cyanamid). C16H14O3; mol wt 254.28.
C 75.57%, H 5.55%, O 18.88%.
Description and references
Prepn: FR 798941 (1936 to I. G. Farbenind.), C.A. 30, 77294 (1936); D. H. Hey, R. Wilkinson, J. Chem. Soc. 1940, 1030; cf. M. Weizmann et al., Chem. Ind. (London) 1940, 402; W. Reppe et al., Ann. 596, 223 (1955); A. S. Tomcufcik et al., DE 2147111; eidem, US 3784701 (1972, 1974 to Am. Cyanamid). Series of articles on chemistry, pharmacology, reproductive toxicology and clinical experience: Arzneim.-Forsch. 30, 695-720, 725-746 (1980). Toxicity: H. F. Bolte et al., ibid. 721. Review of pharmacology and therapeutic use: R. N. Brogden et al., Drugs 21, 1-22 (1981).
Properties
Crystals from ethanol, mp 185-187°. LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte).Therapeutic Category
Anti-inflammatory.
Keywords
Anti-inflammatory (Nonsteroidal); Arylbutyric Acid Derivatives