3975. Fenipentol

Nomenclature

CAS number: 583-03-9
α-Butylbenzenemethanol; α-butylbenzyl alcohol; phenylbutylcarbinol; 1-phenyl-1-hydroxypentane; phenylpentanol; PC 1; Ph BC; Pancoral (Eisai).
C11H16O; mol wt 164.24.
C 80.44%, H 9.82%, O 9.74%.

Description and references

Synthesis: Fourneau, Puyal, An. Soc. Esp. Fis. Quim. 18, 323 (1920); Adams, Vander Werf, J. Am. Chem. Soc. 72, 4368 (1950); Protiva et al., Chem. Listy 46, 37 (1952). Prepn of the drug: Scheffler, Engelhorn, GB 915815; eidem, US 3084100 (both 1963 to Thomae). Pharmacology: Engelhorn, Arzneim.-Forsch. 10, 255 (1960); Beck, Bierwisch, ibid. 20, 693 (1970). Metabolism: Koss et al., ibid. 14, 195 (1964).

Chemical structure

Properties

Colorless or slightly yellow liquid. bp12 123-124°. nD20 1.5112. Miscible with organic liquids. Practically insol in water.

Therapeutic Category

Choleretic. Also used in treatment of mild chronic pancreatitis.

Keywords

Choleretic