3986. Fenoxedil

Nomenclature

CAS number: 54063-40-0
2-(4-Butoxyphenoxy)-N-(2,5-diethoxyphenyl)-N-[2-(diethylamino)ethyl]acetamide; 2-(p-butoxyphenyl)-N-[2-(diethylamino)ethyl]-2′,5′-diethoxyacetanilide.
C28H42N2O5; mol wt 486.64.
C 69.11%, H 8.70%, N 5.76%, O 16.44%.

Description and references

Prepn: DE 1964712; Thuillier, Geffroy, US 3818021 (1970, 1974 both to CERPHA).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 27471-60-9
Suplexedil (Hépatrol).
C28H42N2O5.HCl; mol wt 523.10.
C 64.29%, H 8.29%, N 5.36%, O 15.29%, Cl 6.78%.

Properties

mp 140°. LD50 in mice (mg/kg): 750 orally, 17 i.v. (Thuillier, Geffroy).

Therapeutic Category

Vasodilator.

Keywords

Vasodilator (Cerebral); Vasodilator (Peripheral)