3988. Fenozolone

Nomenclature

CAS number: 15302-16-6
2-(Ethylamino)-5-phenyl-4(5H)-oxazolone; 2-ethylamino-4-oxo-5-phenyl-Δ2-oxazoline; 5-phenyl-2-(ethylimino)-4-oxazolidone; 5-phenyl-2-ethylamino-4-oxazolinone; LD-3394; Ordinator (Dausse).
C11H12N2O2; mol wt 204.23.
C 64.69%, H 5.92%, N 13.72%, O 15.67%.

Description and references

Prepn: Najer, Giudicelli, Bull. Soc. Chim. Fr. 1961, 1231; BE 613985 and DE 1297108 (1962, 1969 both to Dausse), C.A. 57, 13761a (1962); 71, 70586k (1969). Exists predominantly in the tautomeric ethylaminooxazolinone form: Najer et al., Compt. Rend. 254, 2173 (1962). Activity studies: Giudicelli et al., ibid. 2862.

Chemical structure

Properties

Crystals from benzene, mp 148°. Stable in alkaline, unstable in acid soln. uv max (alcohol): 221 nm (log ε 4.42). LD50 in white mice (g/kg): 0.425 orally; 0.175 i.p. (BE 613985).

Therapeutic Category

CNS stimulant.

Keywords

CNS Stimulant