3997. Fenquizone

Nomenclature

CAS number: 20287-37-0
7-Chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide; 7-chloro-2-phenyl-6-sulfamyl-1,2,3,4-tetrahydro-4-quinazolinone; MG-13054.
C14H12ClN3O3S; mol wt 337.78.
C 49.78%, H 3.58%, Cl 10.50%, N 12.44%, O 14.21%, S 9.49%.

Description and references

Thiazide-like diuretic with saluretic and hypocalciuric activity. Prepn: M. G. Biressi et al., Farmaco Ed. Sci. 24, 199 (1969). Prepn of potassium salt: M. Carissimi, F. Ravenna, BE 799087 (1973 to Maggioni); eidem, US 3870720 (1975). Gas-liquid chromatography: A. Marzo et al., J. Chromatogr. 272, 95 (1983). Metabolism in dogs: D. Ceriani et al., Farmaco Ed. Sci. 31, 379 (1976). Human pharmacokinetics: G. C. Maggi et al., Arzneim.-Forsch. 35, 994 (1985). Site of action: C. Ferrando et al., J. Pharm. Pharmacol. 33, 219 (1981). Clinical trials: O. Biadi et al., Drugs Exp. Clin. Res. 7, 763 (1981); N. Glorioso et al., Curr. Ther. Res. 35, 483 (1984); A. Cupisti et al., ibid. 38, 293 (1985).

Chemical structure

Properties

mp >310°. Insol in water.

Derivative

Monopotassium salt.

Nomenclature

CAS number: 52246-40-9
Idrolone (Maggioni).
C14H12ClKN3O3S; mol wt 376.88.
C 44.62%, H 3.21%, Cl 9.41%, K 10.37%, N 11.15%, O 12.74%, S 8.51%.

Properties

White crystalline powder. Sol in water. pH ≈9.9 (1% aqueous soln).

Therapeutic Category

Diuretic.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs