4011. Fepradinol

Nomenclature

CAS number: 63075-47-8
α-[[(2-Hydroxy-1,1-dimethylethyl)amino]methyl]benzenemethanol; 1-phenyl-2-(α,α-dimethylethanolamino)ethanol.
C12H19NO2; mol wt 209.28.
C 68.87%, H 9.15%, N 6.69%, O 15.29%.

Description and references

Prepn: E. Biekert, J. Sonnenbichler, Ber. 95, 1451 (1962); G. Staibano, C. Protto, Farmaco Ed. Sci. 27, 929 (1972); G. Staibano, BE 774629 (1972 to Gentili). Pharmacology: J. M. Masso et al., J. Pharm. Pharmacol. 45, 959 (1993). Mechanism of action study: eidem, Arzneim.-Forsch. 44, 68 (1994). Clinical trial: C. Bestit et al., Curr. Ther. Res. 45, 53 (1989).

Chemical structure

Properties

White cryst from ethanol, mp 142-143°; also reported as mp 140-142° (Staibano). Cryst from benzene, mp 139° (Biekert). uv max (0.1N HCl): 250.5, 256.4, 262.0 nm (log ε 2.17, 2.28, 2.25).

Derivative

Hydrochloride.

Nomenclature

Dalgen (Elmu); Flexidol (Daker-Farmasimes).
C12H19NO2.HCl; mol wt 245.75.
C 58.65%, H 8.20%, N 5.70%, O 13.02%, Cl 14.43%.

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal)