Nomenclature
CAS number: 1185-57-5
2-Hydroxy-1,2,3-propanetricarboxylic acid ammonium iron (3+)
salt; ammonium ferric citrate; iron(III) ammonium citrate; FerriSeltz (Otsuka).
Description and references
Compounds of NH3, iron, and citric
acid of undetermined formula and structure. Prepn: H. J. Kruse,
H. C. Mounce, US 2644828 (1953 to Mallinckrodt). ESR characterization
of green and brown forms: R. A. Uphaus, M. I. Blake, Naturwissenschaften 68, 270 (1981).
Decomposition study: G. A. M. Hussein, Powder
Technol. 80, 265 (1994). Use in prevention
of anemia in pigs: B. G. Harmon et al., J. Anim. Sci. 26, 1051 (1967).
Bioavailability: N. P. Wong et al., Nutr. Rep. Int. 29, 135 (1984). Clinical
evaluation in iron deficiency anemia: M. Taniguchi et al., J. Nutr. Sci. Vitaminol. 37, 161 (1991); of use as an MRI contrast agent: S. Hirohashi et al., Magn. Reson. Imaging 12, 837 (1994).
Properties
Two forms exist. The brown hydrated form exists
as garnet-red transparent scales or granules, or brownish-yellow powder,
and contains ≈9% NH3, 16.5-18.5% Fe, and ≈65% hydrated
citric acid. The green hydrated form exists as green transparent,
deliquesc scales, granules, or powder, and contains ≈7.5% NH3, 14.5-16% Fe, and ≈75% hydrated citric acid. Very sol in water.
Insol in alcohol. Reduced to ferrous salt by light. Keep well closed and protected from light.Use
For blueprints; in photography.
Therapeutic Category
Hematinic.
Therapeutic Category (Veterinary)
In iron deficiency anemia.
Keywords
Hematinic