4038. Ferrocholinate

Nomenclature

CAS number: 1336-80-7
2-Hydroxy-N,N,N-trimethylethanaminium (OC-6-44)-triaqua[2-(hydroxy-κO)-1,2,3-propanetricarboxylato(4)-κO1,κO2]ferrate(1); [hydrogen citrato(3)]triaquoiron, choline salt; iron choline citrate complex.
C11H24FeNO11; mol wt 402.15.
C 32.85%, H 6.02%, Fe 13.89%, N 3.48%, O 43.76%.

Description and references

Chelate prepd by interaction of equimolar quantities of choline dihydrogen citrate and freshly prepd Fe(OH)3 or FeCO3: F. J. Bandelin, US 2575611 (1951 to Flint Eaton); by treatment of a freshly prepd solution of ferric citrate with an equimolar amount of choline: J. K. Chakrabarti, S. P. Sen, Chem. Ind. (London) 1961, 1407. Pediatric use in anemia: J. Rose, Clin. Med. 69, 1601 (1962). Clinical evaluation in iron deficient infants: J. C. Lee, J. Catholic Med. Coll. 30, 479 (1977). Pharmaceutical prepn, characteristics and applications: G. N. Bookwalter et al., J. Food Sci. 38, 618 (1973). Bioavailability in pigs: E. R. Miller et al., J. Anim. Sci. 52, 783 (1981). Brief review in anemia: P. P. Gerbino, K. J. Tietze, Am. J. Pharm. 155, 49-62 (1983).

Chemical structure

Properties

Greenish-brown, reddish-brown or brown amorphous solid with glistening surface upon fracture. Freely sol in water, yielding stable solns; sol in acids, alkalies. One gram of pharmaceutical grade is equivalent to 120 mg of elemental iron and 360 mg of choline base.

Note

Was sold commerically under the names Chel-Iron, Ferrolip, Chelafer. Ferrocholinate is also used for other combinations of iron, choline and citric acid.

Therapeutic Category

Formerly as a hematinic.