4060. Fertilysin
Nomenclature
CAS number: 1477-57-2
N,N′-1,8-Octanediylbis[2,2-dichloroacetamide]; N,N′-octamethylenebis(2,2-dichloroacetamide); N,N′-bis(dichloroacetyl)-1,8-octamethylenediamine; Win-18446. C12H20Cl4N2O2; mol wt 366.11.
C 39.37%, H 5.51%, Cl 38.73%, N 7.65%, O 8.74%.
Description and references
Inhibits spermatogenesis without affecting production of gonadotropins in male laboratory animals. Prepn and biological activity: Surrey, Mayer, J. Med. Pharm. Chem. 3, 419 (1961); Surrey, US 3143566 (1964 to Sterling Drug). Assessment of antifertility activity in rats: S. Nag, J. J. Ghosh, J. Steroid Biochem. 11(1B), 681 (1979). Teratological study: P. Taleporos et al., Teratology 18, 5 (1978). Toxicology study: F. Coulston et al., Toxicol. Appl. Pharmacol. 2, 715 (1960).
