4087. Firocoxib
Nomenclature
CAS number: 189954-96-9
3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone; ML-1785713; Previcox (Merial). C17H20O5S; mol wt 336.40.
C 60.70%, H 5.99%, O 23.78%, S 9.53%.
Description and references
Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: M. Belley et al., WO 9714691; eidem US 5981576 (1997, 1999 both to Merck Frosst). Pharmacokinetics and therapeutic efficacy in inflammatory synovitis in dogs: M. E. McCann et al., Am. J. Vet. Res. 65, 503 (2004).
