4102. Flocoumafen

Nomenclature

CAS number: 90035-08-8
4-Hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]-2H-1-benzopyran-2-one; 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1-naphthyl]; WL-108366; Storm (BASF).
C33H25F3O4; mol wt 542.54.
C 73.06%, H 4.64%, F 10.51%, O 11.80%.

Description and references

Second generation anticoagulant rodenticide. Prepn: I. D. Entwistle, P. Boehm, EP 98629; eidem, US 4520007 (1983, 1985 both to Shell). Synthesis and separation of isomers: O. S. Park, B. S. Jang, Arch. Pharmacal Res. 18, 277 (1995). HPLC determn in liver tissue: A. Jones, Bull. Environ. Contam. Toxicol. 56, 8 (1996). Absorption and distribution in rats: K. R. Huckle et al., Pestic. Sci. 25, 297 (1989). Efficacy against seven rodent species: J. E. Gill, Int. Biodeterior. Biodegrad. 30, 65 (1992). Review of physical properties, mode of action, and field trials: D. J. Bowler et al., Proc. Br. Crop Prot. Conf. - Pests Dis. 1984, 397.

Chemical structure

Properties

White powder. Soly in water: 1.1 mg/l. Soly in acetone, alcohol, chloroform, dichloromethane: >10 g/l. Vapor pressure at 25°: approx 1 × 1013 mm Hg. LD50 in rats, mice, rabbits (mg/kg): 0.25, 0.8, 0.2 orally (Bowler).

Use

Rodenticide.