4121. Flucloronide

Nomenclature

CAS number: 3693-39-8
(6α,11β,16α)-9,11-Dichloro-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; 9,11β-dichloro-6α-fluoro-16α,17,21-trihydroxypregna-1,4-dien-3,20-dione cyclic 16,17-acetal with acetone; 9α,11β-dichloro-6α-fluoro-21-hydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; 6α-fluoro-9α,11β-dichloro-1,4-pregnadiene-16α,17,21-triol-3,20-dione 16,17-acetonide; fluclorolone acetonide; RS-2252; Topilar (Syntex).
C24H29Cl2FO5; mol wt 487.39.
C 59.14%, H 6.00%, Cl 14.55%, F 3.90%, O 16.41%.

Description and references

Prepn: Bowers, US 3201391 (1965 to Syntex). Activity studies: Dorfman et al., Acta Endocrinol. 49, 262 (1965); several authors in Br. J. Dermatol. 82, suppl. 6, 53-98 (1970). Clinical studies: several authors in Clin. Trials J. 8, 35-63 (1971).

Chemical structure

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid