4157. N-2-Fluorenylacetamide

Nomenclature

CAS number: 53-96-3
N-9H-Fluoren-2-ylacetamide; 2-acetylaminofluorene; AAF; 2-FAA.
C15H13NO; mol wt 223.27.
C 80.69%, H 5.87%, N 6.27%, O 7.17%.

Description and references

Synthesis: Hayashi, Nakayama, J. Soc. Chem. Ind. Jpn. [Suppl] 36, 127B (1933). Carcinogenicity studies: R. H. Wilson et al., Cancer Res. 1, 595 (1941). Toxicity studies: Haley et al., Proc. Soc. Exp. Biol. Med. 143, 1117 (1973); 146, 648 (1974).

Chemical structure

Properties

Crystals from alcohol + water, mp 194°. uv max: 285 nm. Insol in water. Sol in alcohols, glycols, fat solvents.

Caution

Potential symptoms of overexposure are reduced function of liver, kidneys, bladder and pancreas. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 4. This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-3.

Use

As a positive control to study the carcinogenicity and mutagenicity of aromatic amines.