4161. Fluoresone

Nomenclature

CAS number: 2924-67-6
1-(Ethylsulfonyl)-4-fluorobenzene; ethyl p-fluorophenyl sulfone; p-fluorophenyl ethyl sulfone.
C8H9FO2S; mol wt 188.22.
C 51.05%, H 4.82%, F 10.09%, O 17.00%, S 17.04%.

Description and references

Prepn: G. Thuillier et al., Compt. Rend. 248, 2492 (1959); P. Rumpf, G. Thuillier, FR M399; eidem, US 3084101 (1962, 1963 both to Centre Nat. Recher. Scient.); A. A. Mignot, P. Rumpf, Bull. Soc. Chim. Fr. 1968, 435. Pharmacology: J. Thuillier et al., Proc. 3rd Meet Coll. Int. Neuro-Psychopharmacol. 1962, 317-326 (Publ. 1964). Clinical evaluation: H. Akimoto, S. Taen, ibid. 326. Gas chromatography: E. Marozzi et al., Farmaco Ed. Prat. 31, 180 (1976).

Chemical structure

Properties

Crystals, mp 41°. LD50 in mice (mg/kg): 850 orally; 550 i.p. (J. Thuillier); also reported as 542 orally; 343 i.p. (Akimoto, Taen).

Therapeutic Category

Anticonvulsant.