4183. Fluosol DA

Nomenclature

CAS number: 75216-20-5

Description and references

Biologically inert fluorocarbon emulsion of perfluorodecalin and perfluorotripropylamine that performs the oxygen-carrying function of red blood cells. Has a particle size of 0.05 to 0.25μ and is stable at room temperature for years. Can be administered regardless of blood type; does not carry hepatitis or other infectious diseases. Prepn: K. Yokoyama et al., DE 2630586; eidem, US 4252827 (1977, 1981 to Green Cross). Hemodynamic and oxygen transport effects: K. K. Tremper et al., Crit. Care Med. 8, 738 (1980). Clinical studies: H. Ohyanagi et al., Clin. Ther. 2, 306 (1979); T. Suyama et al., Prog. Clin. Biol. Res. 55, 609 (1981); T. Mitsuno et al., Ann. Surg. 195, 60 (1982). Review: Int. Congr. Ser. 486, 1-471 (1979). Review of use as red cell substitute: K. C. Lowe, Comp. Biochem. Physiol. 87A, 825-838 (1987).

Properties

20% Emulsion, FDA-20. Viscosity at 37°: 2.3 cP. pH 7.4.

Derivative

Perfluorodecalin.

Nomenclature

CAS number: 306-94-5
Octadecafluorodecahydronaphthalene; perflunafene; FDC.
C10F18; mol wt 462.08.
C 25.99%, F 74.01%.

Description and references

Prepn: E. T. McBee, L. D. Bechtol, Ind. Eng. Chem. 39, 380 (1947).

Properties

mp 10 to 7°. bp 140°. d420 1.9456. nD20 1.3118. Vapor pressure at 37°: 12.7 mm Hg.

Derivative

Perfluorotripropylamine.

Nomenclature

CAS number: 338-83-0
1,1,2,2,3,3,3-Heptafluoro-N,N-bis(heptafluoropropyl)-1-propanamine; heneicosafluorotripropylamine; perfluamine; FTPA.
C9F21N; mol wt 521.07.
C 20.75%, F 76.57%, N 2.69%.

Description and references

Prepn: R. N. Haszeldine, J. Chem. Soc. 1951, 102.

Properties

bp 129.5-130.5°. d425 1.822. nD25 1.279. Vapor press. at 37°: 20.0 mm Hg.

Therapeutic Category

Blood substitute.

Keywords

Blood Substitute