4188. Fluperolone Acetate

Nomenclature

CAS number: 2119-75-7
[11β,17α,17(S)]-17-[2-(Acetyloxy)-1-oxopropyl]-9-fluoro-11,17-dihydroxyandrosta-1,4-dien-3-one; 9-fluoro-11β,17α-dihydroxy-17(S)-lactoylandrosta-1,4-dien-3-one 17β-acetate; 9α-fluoro-11β,17α,21-trihydroxy-21-methylpregna-1,4-diene-3,20-dione 21-acetate; 17β-[2-acetoxypropionyl]-9α-fluoro-11β,17-dihydroxyandrosta-1,4-dien-3-one; 21-methyl-9α-fluoroprednisolone acetate; P-1742; ALAcortril (Pfizer); Methral (Pfizer).
C24H31FO6; mol wt 434.50.
C 66.34%, H 7.19%, F 4.37%, O 22.09%.

Description and references

Prepn: E. J. Agnello et al., Experientia 16, 357 (1960); eidem, J. Org. Chem. 28, 1531 (1963); E. J. Agnello, G. D. Laubach, US 3234095 (1966 to Pfizer). Activity studies: Child et al., Arch. Dermatol. 97, 407 (1968).

Chemical structure

Properties

Crystals, mp 251-253°. [α]D +87°. uv max: 239 nm (ε 15350).

Therapeutic Category

Glucocorticoid; anti-inflammatory.

Keywords

Glucocorticoid