4202. Fluroxene

Nomenclature

CAS number: 406-90-6
(2,2,2-Trifluoroethoxy)ethene; 2,2,2-trifluoroethyl vinyl ether; Fluoromar (formerly) (Ohio Med.).
C4H5F3O; mol wt 126.08.
C 38.11%, H 4.00%, F 45.21%, O 12.69%.

Description and references

First clinical fluorinated inhalation anesthetic agent. Prepd (not claimed): J. G. Shukys, US 2830007; P. W. Townsend, US 2870218 (1958, 1959 to Air Reduction). Anesthetic action: J. C. Krantz, Jr. et al., J. Pharmacol. Exp. Ther. 108, 488 (1953). Review of metabolism and toxicity: V. Fiserova-Bergerova, Environ. Health Perspect. 21, 225-230 (1977); L. S. Kaminsky, J. M. Fraser, Crit. Rev. Toxicol. 19, 87-112 (1988).

Chemical structure

Properties

Liquid. bp751 42.5°. nD20 1.3192. d204 1.135. Potentially explosive.

Caution

Potential symptoms of overexposure are eye irritation; CNS depression, analgesia, anesthesia, seizures, respiratory depression. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 146.

Therapeutic Category

Formerly as anesthetic (inhalation).