4209. Flutazolam

Nomenclature

CAS number: 27060-91-9
10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one; MS-4101; Ro-7-6102; Coreminal (Mitsui).
C19H18ClFN2O3; mol wt 376.81.
C 60.56%, H 4.81%, Cl 9.41%, F 5.04%, N 7.43%, O 12.74%.

Description and references

Tricyclic benzodiazepine deriv. Prepn: BE 765253; M. E. Derieg et al., US 3905956 (1971, 1975 both to Hoffmann-La Roche). Physicochemical properties: A. Ito et al., Iyakuhin Kenkyu 9, 787 (1978), C.A. 89, 169013e (1979). Psychopharmacological profile: T. Mitsushima, S. Ueki, Folia Pharmacol. Jpn. 74, 959 (1978), C.A. 90, 180083u (1979). Toxicological studies: K. Ishimura et al., Oyo Yakuri 15, 1081 (1978); eidem, ibid. 16, 693 (1978), C.A. 90, 16379z, 145909p (1979).

Chemical structure

Properties

White prisms from toluene, mp 142-147°. pKa 5.40. Freely sol in chloroform, ethanol. Moderately sol in acetone, benzene, methanol. Practically insol in water.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Benzodiazepine Derivatives