4214. Flutriafol

Nomenclature

CAS number: 76674-21-0
α-(2-Fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol; (RS)-2,4′-difluoro-α-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol; flutriafen; R-152450; PP-450; Impact (Zeneca).
C16H13F2N3O; mol wt 301.29.
C 63.78%, H 4.35%, F 12.61%, N 13.95%, O 5.31%.

Description and references

Prepn: K. P. Parry et al., EP 15756 (1980 to ICI). Activity, physical properties, and toxicology: A. M. Skidmore et al., Proc. 10th Int. Congr. Plant Prot. 1, 368 (1983). Mode of action: B. C. Baldwin et al., Meded. Fac. Landbouwwet. Rijksuniv. Gent 49, 303 (1984). Field trials: P. J. Northwood et al., Proc. 10th Int. Congr. Plant Prot. 3, 930 (1983); J. S. Brown, Crop Prot. 6, 157 (1987).

Chemical structure

Properties

White crystalline solid, mp 130°. Vapor pressure at 20°: 3.00 × 109 mm Hg. Soly at 20° (g/l): acetone 190; dichloromethane 150; hexane 0.30; methanol 69; xylene 12; water (pH 7.0) 0.13. LD50 male, female rats (mg/kg): 1140, 1480 orally; rats, rabbits: >1000, >2000 percutaneously (Skidmore).

Use

Agricultural fungicide.