4219. Fluvoxamine

Nomenclature

CAS number: 54739-18-3
(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime; 5-methoxy-4′-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime.
C15H21F3N2O2; mol wt 318.33.
C 56.60%, H 6.65%, F 17.90%, N 8.80%, O 10.05%.

Description and references

Selective serotonin reuptake inhibitor (SSRI). Prepn: NL 7503310; H. B. A. Welle, V. Claassen, US 4085225 (1975, 1978 both to Philips-Duphar). Inhibition of 5-HT uptake: V. Claassen et al., Br. J. Pharmacol. 60, 505 (1977). HPLC determn in plasma: G. J. De Jong, J. Chromatogr. 183, 203 (1980). Series of articles on pharmacology, pharmacokinetics and clinical trials in depression: Br. J. Clin. Pharmacol. 15, Suppl. 3, 347S-450S (1983). Clinical trial in obsessive-compulsive disorder: L. M. Koran et al., J. Clin. Psychopharmacol. 16, 121 (1996). Review of clinical experience in depression: M. R. Ware, J. Clin. Psychiatry 58, Suppl. 5, 15-23 (1997); in obsessive-compulsive disorder: B. Dell'Osso et al., Expert Opin. Pharmacother. 6, 2727-2740 (2005).

Chemical structure

Derivative

Maleate.

Nomenclature

CAS number: 61718-82-9
DU-23000; MK-264; Dumirox (Solvay); Faverin (Solvay); Fevarin (Solvay); Floxyfral (Solvay); Luvox (Solvay); Maveral (Farmades).
C15H21F3N2O2.C4H4O4; mol wt 434.41.
C 52.53%, H 5.80%, F 13.12%, N 6.45%, O 22.10%.

Properties

Crystals from acetonitrile, mp 120-121.5°. Freely sol in ethanol, chloroform; sparingly sol in water. Practically insol in diethyl ether.

Therapeutic Category

Antidepressant; antiobsessional.

Keywords

Antidepressant; Antiobsessional; Serotonin Uptake Inhibitor