Description and references

Pyrophosphate analog; inhibits viral DNA polymerase and reverse transcriptase. Prepn: P. Nylén, Ber. 57B, 1023 (1924). Crystal structure: R. R. Naqvi et al., J. Chem. Soc. A 1971, 2751; S. C. Abrahams, Acta Crystallogr. B28, 2886 (1972). Activity against herpes simplex virus: E. Helgstrand et al., Science 201, 819 (1978). Effect on HIV-1 reverse transcriptase: P. S. Sarin et al., Biochem. Pharmacol. 34, 4075 (1985). HPLC determn in plasma: B. B. Ba et al., J. Chromatogr. B 724, 127 (1999); in pharmaceutical formulations: J. Garcia et al., Biomed. Chromatogr. 20, 1024 (2006). Series of articles on pharmacology and clinical experience in cytomegalovirus retinitis: Am. J. Med. 92, Suppl. 1, S1-S35 (1992). Clinical trial in multi-drug resistant HIV infection: A. Canestri et al., Antivir. Ther. 11, 561 (2006).

Derivative