Description and references

Inhibitor of microbial nonmevalonate isoprenoid biosynthesis. Prepn: T. Kamiya et al., US 4206156 (1980 to Fujisawa); K. Hemmi et al., Chem. Pharm. Bull. 29, 646 (1981); eidem, ibid. 30, 111 (1982). Synthesis: E. Ohler, S. Kanzler, Synthesis 1995, 539 (1995). CE determn in serum and urine: S. Bronner et al., J. Chromatogr. B 806, 255 (2004). Mode of action: T. Kuzuyama et al., Tetrahedron Lett. 39, 7913 (1998); H. Jomaa et al., Science 285, 1573 (1999). Pharmacokinetics: T. Murakawa et al., Antimicrob. Agents Chemother. 21, 224 (1982); H.-P. Kuemmerle et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 515, 521 (1985). Clinical evaluation in malaria: M. A. Missinou et al., Lancet 360, 1941 (2002); in combination with clindamycin: S. Borrmann et al., J. Infect. Dis. 189, 901 (2004); idem et al., ibid. 190, 1534 (2004). Interaction with other antimalarial drugs and synergy with clindamycin: J. Wiesner et al., Antimicrob. Agents Chemother. 46, 2889 (2002). Review: idem et al., Parasitol. Res. 90, S71-S76 (2003).

Properties

Derivative