Occurs in seaweed: Ascophyllum nodosum (L.) Ledol. (Fucus nodosus L.), Fucus vesiculosus L., F. serratus L., F. virsoides (Don) J. Ag., Fucaceae, and in gum tragacanth. Isoln from seaweed: Clark, J. Biol. Chem. 54, 65 (1922); Hockett et al., J. Am. Chem. Soc. 61, 1658 (1939). Manuf from fucoidan: Schweiger, US 3240775 (1966 to Kelco). Synthesis from d-galactose: Dejterjuszynski, Flowers, Carbohydr. Res. 28, 144 (1973); from d-glucose: T. Chiba, S. Tejima, Chem. Pharm. Bull. 27, 2838 (1979); from d-mannose: J. Defaye et al., Carbohydr. Res. 94, 131 (1981). Review of chemistry and biochemistry: H. M. Flowers, Adv. Carbohydr. Chem. Biochem. 39, 279-345 (1981).