4378. Gefarnate

Nomenclature

CAS number: 51-77-4
(4E,8E)-5,9,13-Trimethyl-4,8,12-tetradecatrienoic acid (2E)-3,7-dimethyl-2,6-octadienyl ester; geranyl farnesylacetate; DA-688; Alsanate (Dainippon); Arsanyl (Taiyo); Dixnalate (Sana); Gefanil (Sumitomo); Gefarnil; Gefarnyl; Gefulcer (Ohta); Osteol (Yamanouchi); Salanil (Sato Yakuhin); Zackal (SS Pharm.).
C27H44O2; mol wt 400.64.
C 80.94%, H 11.07%, O 7.99%.

Description and references

Prepn: Cardani et al., J. Med. Chem. 6, 457 (1963); BE 617994 (1962 to Ist. de Angeli). Metabolism: G. Coppi et al., Arzneim.-Forsch. 19, 1519 (1969). Clinical evaluation in duodenal ulcer: C. R. Newman, D. A. Montgomery, Br. J. Clin. Pract. 27, 85 (1973).

Chemical structure

Properties

Slightly yellowish liquid with weak terpenic smell. bp0.05 165-168°. nD20 1.4900. uv max: 204 nm (E1%1cm 486). Sol in alc, ether, dimethylformamide, acetone, fatty oils. Practically insol in water, formamide, ethylene glycol, propylene glycol, glycerine.

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative