4414. Gestonorone Caproate

Nomenclature

CAS number: 1253-28-7
17-[(1-Oxohexyl)oxy]-19-norpregn-4-ene-3,20-dione; 17-hydroxy-19-norpregn-4-ene-3,20-dione hexanoate; 17α-hydroxy-19-norprogesterone caproate; 17β-acetyl-17-hydroxyestr-4-ene-3-one hexanoate; gestronol caproate; SH-582; Depostat (Schering AG).
C26H38O4; mol wt 414.58.
C 75.32%, H 9.24%, O 15.44%.

Description and references

Prepn: Popper et al., Arzneim.-Forsch. 19, 352 (1969); Popper et al., DE 1074582 (1960 to Schering). Pharmacological studies: Junkmann, Anglo-Ger. Med. Rev. 1, 385 (1962). Metabolism: Breuer, Lisboa, Acta Endocrinol. 51, 114 (1966).

Chemical structure

Properties

Crystals, mp 123-124°. [α]D +13° (chloroform). uv max: 239 nm (ε 17540).

Therapeutic Category

Progestogen; in treatment of prostatic hypertrophy.

Keywords

Antiprostatic Hypertrophy; Progestogen