4494. Glycocholic Acid
Nomenclature
CAS number: 475-31-0
N-[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine; N-cholylglycine. C26H43NO6; mol wt 465.62.
C 67.07%, H 9.31%, N 3.01%, O 20.62%.
Description and references
The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt. Prepn from bile: Hammarsten in Abderhalden's Handbuch der Biol. Arbeitsmethoden, Abt. I, Teil 6, p 211 (1925). Prepn from cholic acid: Cortese, J. Am. Chem. Soc. 59, 2532 (1937). Synthesis: Cortese, Bauman, ibid. 57, 1393 (1935); Bergstrom, Norman, Acta Chem. Scand. 7, 1126 (1953). Separation: Antonides, GB 928635 (1963 to Armour). Metabolism: Norman, Scand. J. Gastroenterol. 5, 231 (1970).
Derivative
Sesquihydrate.Properties
Crystals from 5% alc, mp about 130°. [α]D23 +30.8° (c = 7.5 in 95% ethanol). Anhydr form, mp 165-168°. pK 4.4. Soly in water at 15°: 0.33 g/l; in boiling water: 8.3 g/l. Is hydrolyzed to cholic acid and glycine by acids and alkalies. Forms addition compds with nitrobenzene, aniline, benzyl alcohol, benzaldehyde, triolein.Derivative
Sodium salt.C26H42NNaO6; mol wt 487.60.
C 64.04%, H 8.68%, N 2.87%, Na 4.71%, O 19.69%.