Nomenclature
CAS number: 15283-45-1
Trisodium (
T-4)-bis[monothiosulfato(2)-κ
O,κS]-aurate(3); hyposulfite of gold and sodium; sodium aurothiosulfate; Aurocidin; Aurolin (UCB); Crisalbine; Fosfocrisolo (Zambon); Sanocrysin.
AuNa
3O
6S
4; mol wt 490.19.
Au 40.18%, Na 14.07%, O 19.58%, S 26.17%.
Na
3Au(S
2O
3)
2.
Description and references
Prepn of dihydrate: Fordos, Gélis, Ann. Chim. Phys. 13, 394 (1845);
H. Brown, J. Am. Chem. Soc. 49, 958 (1927); Roger's Inorganic Pharmaceutical Chemistry, T. O. Soine, C. O. Wilson, Eds. (Lea & Febiger, Philadelphia,
8th ed., 1967) pp 343-345. Crystal structure of dihydrate: H. Ruben et al., Inorg. Chem. 13, 1836 (1974). Efficacy of antidotes: M. A. Basinger et al., J. Rheumatol. 12, 274 (1985). Clinical study of contact allergy patch test
reactions: K. E. McKenna et al., Contact Dermatitis 32, 143 (1995). Clinical
evaluation in rheumatoid arthritis: M. L. Ciompi et al., Reumatismo 54, 251
(2002).
Derivative
Dihydrate.
Nomenclature
CAS number: 33614-49-2
Properties
White, glistening, needle-like or prismatic crystals.
d 3.14. Darkens slowly
on exposure to light. One gram dissolves in 2 ml water. Insol in
alc and most other organic solvents. A 1:20 aq soln is neutral or
slightly alkaline to litmus. LD50 i.p. in mice: 110 mg/kg (Basinger).Caution
Potential symptoms of overexposure
via therapeutic i.m. administration are dermatitis, nausea, vomiting,
diarrhea, nephritis, blood disorders, peripheral neuritis, hepatitis,
encephalitis. See Clinical Toxicology
of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) p II-144.Therapeutic Category
Antirheumatic; diagnostic aid (contact allergen).
Keywords
Antiarthritic/Antirheumatic; Diagnostic Aid