Description and references

Fluorinated quinolone antibacterial. Prepn: J. M. Domagala et al., WO 8906649; eidem, US 4920120 (1989, 1990 both to Warner-Lambert); S. E. Hagen et al., J. Med. Chem. 34, 1155 (1991). Comparative in vitro activity: F. Marco et al., J. Antimicrob. Chemother. 33, 647 (1994); R. C. Arduino et al., ibid. 34, 403. HPLC determn in human bronchoalveolar lavage samples: J. M. Woodcock et al., FEMS Microbiol. Lett. 119, 315 (1994). Clinical pharmacokinetics: J. Child et al., Antimicrob. Agents Chemother. 39, 513 (1995). Tissue concentration in lung: P. J. Cook et al., J. Antimicrob. Chemother. 35, 317 (1995). Review of pharmacology and clinical trials: A. J. Wagstaff, J. A. Balfour, Drugs 53, 817-824 (1997).

Derivative

Derivative