4586. Hachimycin

Nomenclature

CAS number: 1394-02-1
Trichomycin; Trichonat (Grünenthal).

Description and references

Heptaene macrolide antibiotic substance produced by Streptomyces hachijoensis from soil of the Pacific Island Hachijo Jima: S. Hosoya et al., J. Antibiot. 5, 564 (1952); T. Yamaguchi, ibid. 7A, 10 (1954). Purification and prepn of insol derivs: S. Hosoya et al., ibid. 8A, 5 (1955). At one time, trichomycin was believed to be identical to candicidin and hamycin, q.q.v.: H. Burrows, D. Calam, J. Chromatogr. 53, 566 (1970). Subsequent HPLC studies have shown the three polyene antibiotics to be different entities: P. Helboe et al., ibid. 189, 249 (1980). Active against Trichomonas vaginalis, Treponema pallidum, Trichophyton, Candida, and yeast, weak activity against Aspergillus and Penicillium: T. Yamaguchi, J. Antibiot. 7A, 10 (1954). Toxicity: S. Hosoya et al., J. Antibiot. 6A, 98 (1953). Review: S. A. Waksman, H. A. Lechevalier, The Actinomycetes vol. III (Williams & Wilkins, Baltimore, 1962) pp 397-399.

Properties

Yellow crystals. Acid reaction. Forms a water-sol sodium salt. Can be pptd as a water-insol salt by acridine derivs such as acriflavine, by sulfa drugs such as homosulfanilamide, by basic antibiotics such as streptomycin base, by enzymes such as papain and lysozyme, by dyes such as methylene blue, and by metallic salts such as CaCl2. LD50 i.p. in mice: 0.05 mg/10-12 g mouse (Hosoya).

Therapeutic Category

Antifungal. Antiprotozoal (Trichomonas).

Keywords

Antifungal (Antibiotics); Polyenes; Antiprotozoal (Trichomonas)