4597. Halometasone

Nomenclature

CAS number: 50629-82-8
(6α,11β,16α)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 2-chloroflumethasone; C-48401-Ba.
C22H27ClF2O5; mol wt 444.90.
C 59.39%, H 6.12%, Cl 7.97%, F 8.54%, O 17.98%.

Description and references

Synthetic corticosteroid. Prepn: G. G. Anner et al., NL 540244; eidem, US 3652554; eidem, CH 551399, C.A. 81, 120864d (1974) (1968, 1972, 1974 all to Ciba-Geigy). Series of clinical trials in eczema, psoriasis, dermatomycoses, bacterial infections: J. Int. Med. Res. 11, Suppl. 1 (1983).

Chemical structure

Properties

mp 220-222° (dec).

Derivative

Monohydrate.

Nomenclature

Sicorten (Novartis).
C22H27ClF2O5.H2O; mol wt 462.91.
C 57.08%, H 6.31%, Cl 7.66%, F 8.21%, O 20.74%.

Therapeutic Category

Anti-inflammatory (topical); antipruritic.

Keywords

Antipruritic; Glucocorticoid