4636. Hematoporphyrin

Nomenclature

CAS number: 14459-29-1
7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid; 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionic acid; 1,3,5,8-tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid; hematoporphyrin IX; Photodyn.
C34H38N4O6; mol wt 598.69.
C 68.21%, H 6.40%, N 9.36%, O 16.03%.

Description and references

Prepd from hemin by the action of hydrobromic acid in glacial acetic acid: Fischer-Orth, Die Chemie des Pyrrols II, 1, 421 (Leipzig, 1937). Review and prepn: J. E. Falk, Porphyrins and Metalloporphyrins (Elsevier, New York, 1964) pp 175-177.

Chemical structure

Properties

Deep red crystals. Absorption max (0.1N KOH): 615.5, 565, 534.4, 499.5 nm. Insol in water. Sol in alc. Sparingly sol in ether, chloroform.

Derivative

Hydrochloride monohydrate.

Nomenclature

CAS number: 6033-08-5
Sensibion.
C34H38N4O6.HCl.H2O; mol wt 653.16.
C 62.52%, H 6.33%, N 8.58%, O 17.15%, Cl 5.43%.

Description and references

Prepn of a stable product: Woods, Steigman, US 2858320 (1958 to Baxter Labs.).

Properties

Dark red crystals.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant