4657. Heptaminol

Nomenclature

CAS number: 372-66-7
6-Amino-2-methyl-2-heptanol; 2-methyl-6-amino-2-heptanol; 6-methyl-2-amino-6-heptanol.
C8H19NO; mol wt 145.24.
C 66.16%, H 13.19%, N 9.64%, O 11.02%.

Description and references

Prepn: H. T. F. Givens, R. M. Herbst, US 2457656 (1948 to Bilhuber); of hydrochloride: J. Doeuvre, J. Poizat, Compt. Rend. 224, 286 (1947). Pharmacokinetics and metabolism: F. Chanoine et al., Arzneim.-Forsch. 31, 1430 (1981). HPLC determn in biological fluids: R. R. Brodie et al., J. Chromatogr. 274, 179 (1983). Clinical trial in hypotension: D. Milon et al., Fundam. Clin. Pharmacol. 4, 695 (1990). Review of mode of action: B. Pourrias Ann. Pharm. Fr. 49, 127-138 (1991).

Chemical structure

Properties

Colorless liquid, bp7 92-93°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 543-15-7
RP-2831; Cortensor; Eoden (Woelm); Hept-a-myl (Delalande); Heptylon (Delalande).
C8H19NO.HCl; mol wt 181.70.
C 52.88%, H 11.09%, N 7.71%, O 8.81%, Cl 19.51%.

Properties

Crystals, mp 150°. Freely sol in water. Sol in alcohol. Practically insol in acetone, benzene, ether. pH of 2% aq soln: 4.5-5.5.

Derivative

5′-Adenylate.

Nomenclature

CAS number: 57249-13-5
Ampecyclal (Sarget).

Therapeutic Category

Antihypotensive.

Keywords

Cardiotonic