4682. Hexadimethrine Bromide

Nomenclature

CAS number: 28728-55-4
N,N,N′,N′-Tetramethyl-1,6-hexanediamine polymer with 1,3-dibromopropane; polymer of N,N,N′,N′-tetramethylhexamethylenediamine and trimethylene bromide; poly(N,N,N′,N′-tetramethyl-N-trimethylenehexamethylenediammonium dibromide); Polybrene.

Description and references

(C13H30Br2N2)x. Toxicity study: Kimura et al., Toxicol. Appl. Pharmacol. 1, 185 (1959).

Chemical structure

Properties

White, hygroscopic, amorphous polymer. Soluble in water up to 10%. pH of 1% saline soln 5-9. Stable in soln and when autoclaved. Polymers with mol wt of 5000-10,000 have LD50 i.v. in mice: 25-40 mg/kg (Kimura).

Therapeutic Category

Heparin antagonist.

Keywords

Heparin Antagonist