4703. Hexetidine

Nomenclature

CAS number: 141-94-6
1,3-Bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidinamine; 5-amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine; 1,3-bis(β-ethylhexyl)-5-methyl-5-aminohexahydropyrimidine; 5-amino-1,3-di(β-ethylhexyl)hexahydro-5-methylpyrimidine; Glypesin (Stada); Hexigel (Warner-Lambert); Hexocil (Pharmacia); Hexoral (Pfizer); Hextril (Pfizer); Oraldene (Pfizer); Oraseptic (Warner-Lambert); Sterisil (Warner-Lambert); Steri/Sol (Warner-Lambert).
C21H45N3; mol wt 339.60.
C 74.27%, H 13.36%, N 12.37%.

Description and references

Prepn: Senkus, J. Am. Chem. Soc. 68, 1611 (1946); US 2415047; Bell, Necker, US 3054797 (1947, 1962 both to Comm. Solvents Corp.). Comprehensive description: G. Satzinger et al., Anal. Profiles Drug Subs. 7, 277-295 (1978).

Chemical structure

Properties

Liquid. d2020 0.8889. bp0.4 160°. nD20 1.4668. Sol in petr ether, methanol, benzene, acetone, ethanol, n-hexane, chloroform. Practically insol in water. pKa 8.3. Has good thermal stability.

Therapeutic Category

Antiseptic.

Therapeutic Category (Veterinary)

Antiseptic.

Keywords

Antifungal (Synthetic)