4708. Hexylcaine Hydrochloride

Nomenclature

CAS number: 532-76-3
1-(Cyclohexylamino)-2-propanol benzoate (ester) hydrochloride; D-109; Cyclaine (Merck & Co.).
C16H24ClNO2; mol wt 297.82.
C 64.53%, H 8.12%, Cl 11.90%, N 4.70%, O 10.74%.

Description and references

Prepn: Cope, Hancock, J. Am. Chem. Soc. 66, 1453 (1944); Cope, US 2486374 (1949 to Sharp & Dohme). Pharmacokinetics: R. M. Rodgers et al., Res. Commun. Chem. Pathol. Pharmacol. 29, 99 (1980).

Chemical structure

Properties

Crystals from abs alc, mp 177-178.5°. Soluble in water to the extent of about 12% w/w. A 1% soln is stable to boiling and autoclaving for sterilization purposes.

Therapeutic Category

Anesthetic (local).

Therapeutic Category (Veterinary)

Anesthetic (local).

Keywords

Anesthetic (Local)