4733. Homochlorcyclizine

Nomenclature

CAS number: 848-53-3
1-[(4-Chlorophenyl)phenylmethyl]hexahydro-4-methyl-1H-1,4-diazepine; N-(p-chlorobenzhydryl)-N′-methylhomopiperazine; 1-(4-chlorodiphenylmethyl)-4-methyl-2,3,4,5,6,7-hexahydro-1,4-diazepine; 1-(p-chloro-α-phenylbenzyl)-4-methylhomopiperazine; SA-97.
C19H23ClN2; mol wt 314.85.
C 72.48%, H 7.36%, Cl 11.26%, N 8.90%.

Description and references

Prepn: Weston, Sommers, US 2655498 (1953 to Abbott); eidem, J. Am. Chem. Soc. 76, 5805 (1954). HPLC determn of enantiomers in urine: M. Nishikata et al., J. Chromatogr. 612, 239 (1993).

Chemical structure

Properties

bp0.8 177°. nD25 1.5804.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 1982-36-1
Curosajin (Merck KGaA); Homoclomin (Eisai).
C19H23ClN2.2HCl; mol wt 387.77.
C 58.85%, H 6.50%, Cl 27.43%, N 7.22%.

Properties

Crystals from ethanol, mp 227-228°.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Piperazines