4750. HPA-23

Nomenclature

CAS number: 89899-81-0
Hexaoctacontaoxononaantimonateheneicosatungstate(19) heptadecaammonium disodium; ammonium 5-tungsto-2-antimonate; 5-tungsto-2-antimonate; 21-tungsto-9-antimonate.
H68Na2N17O86Sb9W21; mol wt 6685.06.
H 1.03%, Na 0.69%, N 3.56%, O 20.58%, Sb 16.39%, W 57.75%.
(NH4)17Na(NaSb9W21O86).

Description and references

One of the condensed mineral heteropolyanions, also called polyoxotungstates. Synthesis: M. Michelon, G. Hervé, C. R. Seances Acad. Sci. Ser. C 274, 209 (1972); M. Michelon et al., J. Inorg. Nucl. Chem. 42, 1583 (1980). Crystal structure: J. Fischer et al., J. Am. Chem. Soc. 98, 3050 (1976). Laser Raman studies of intracellular localization: C. Cibert, C. Jasmin, Biochem. Biophys. Res. Commun. 108, 1424 (1982). Antiviral activity in mice: C. Jasmin et al., J. Natl. Cancer Inst. 53, 469 (1974); G. H. Werner et al., J. Gen. Virol. 31, 59 (1976). In vitro inhibition of rabies virus: H. Tsiang et al., J. Gen. Virol. 40, 665 (1978). Effects in scrapie model systems: R. H. Kimberlin, C. A. Walker, Lancet 2, 591 (1979); eidem, Arch. Virol. 78, 9 (1983). Structure-activity study: M. Hervé et al., Biochem. Biophys. Res. Commun. 116, 222 (1983). Clinical evaluation in AIDS: W. Rozenbaum et al., Lancet 1, 450 (1985); B. L. Moskovitz, Antimicrob. Agents Chemother. 32, 1300 (1988).

Properties

Crystals from water. Solution has pH near 6.7, and is stable around neutrality. LD50 i.p. in mice: 750 mg/kg (Werner).

Note

Formerly known as ammonium antimony tungsten oxide.