4857. Hyodeoxycholic Acid

Nomenclature

CAS number: 83-49-8
(3α,5β,6α)-3,6-Dihydroxycholan-24-oic acid; 3α,6α-dihydroxy-5β-cholanic acid; α-hyodeoxycholic acid; hyodesoxycholic acid.
C24H40O4; mol wt 392.57.
C 73.43%, H 10.27%, O 16.30%.

Description and references

Isoln from pig bile: Wieland, Gumlich, Z. Physiol. Chem. 215, 18 (1933); Trickey, US 2547726 (1951 to U.S. Rubber); Fogle, US 2745849 (1956 to Armour); Buckley, Ziegler, US 2758120 (1956 to Canada Packers); Liebig, US 3006927 (1961 to Riedel-de Haen). Configuration: Moffett, Hoehn, J. Am. Chem. Soc. 69, 1995 (1947).

Chemical structure

Properties

Crystals from ethyl acetate, mp 196-197°. [α]D20 +8° (alc). Moderately sol in ethanol, glacial acetic acid. Less sol in ether, acetone, ethyl acetate, benzene.