4871. IACFT

Nomenclature

CAS number: 180468-34-2
(1R,2S,3S,5S)-3-(4-Fluorophenyl)-8-[(2E)-3-(iodo-2-propenyl)]-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester; 2β-carboxymethoxy-3β-(4-fluorophenyl)-N-(1-iodoprop-1-en-3-yl)nortropane; Altropane (Organix).
C18H21FINO2; mol wt 429.27.
C 50.36%, H 4.93%, F 4.43%, I 29.56%, N 3.26%, O 7.45%.

Description and references

Cocaine analog with dopamine transport inhibitor activity. Radiolabeled form designed for SPECT brain imaging. Prepn: D. R. Elmaleh et al.,WO 9511901; eidem, US 5493026 (1995, 1996 both to Gen. Hosp. Corp., Harvard College, Organix and Northeastern Univ.); and receptor binding studies: eidem, J. Nucl. Med. 37, 1197 (1996). Series of articles on pharmacology and binding studies: B. K. Madras et al., Synapse 29, 93-127 (1998). Clinical evaluation in Parkinson's disease: A. J. Fischman et al., ibid. 128. CE determn in plasma: K. Hettiarachchi et al., J. Chromatogr. A 895, 87 (2000).

Chemical structure

Properties

White solid, mp 115-116°,

Derivative

123I-Labeled form.

Nomenclature

CAS number: 208517-65-1

Derivative

125I-Labeled form.

Nomenclature

CAS number: 180268-78-4

Therapeutic Category

123I-labeled form as diagnostic aid (radioactive imaging agent).

Keywords

IACFT 123I: Diagnostic Aid (Radioactive Imaging Agent)