4880. Ibufenac

Nomenclature

CAS number: 1553-60-2
4-(2-Methylpropyl)benzeneacetic acid; (p-isobutylphenyl)acetic acid; p-isobutyl-α-toluic acid; Dytransin.
C12H16O2; mol wt 192.25.
C 74.97%, H 8.39%, O 16.64%.

Description and references

Non-sterodial anti-inflammatory drug (NSAID). Prepn: J. S. Nicholson, S. S. Adams, GB 971700; eidem, US 3385887 (1964, 1968 both to Boots Pure Drug). Pharmacology: S. S. Adams et al., J. Pharm. Pharmacol. 20, 305 (1968). Toxicity data: S. S. Adams et al., Nature 200, 271 (1962).

Chemical structure

Properties

Crystals, mp 85-87°. Very slightly sol in water. Freely sol in many organic solvents. LD50 orally in mice: 1.8 g/kg (Adams).

Therapeutic Category

Analgesic, anti-inflammatory.