4930. Indalpine

Nomenclature

CAS number: 63758-79-2
3-[2-(4-Piperidinyl)ethyl]-1H-indole; 4-[2-(3-indolyl)ethyl]piperidine; LM-5008; Upstene (Pharmuka).
C15H20N2; mol wt 228.33.
C 78.90%, H 8.83%, N 12.27%.

Description and references

Selective serotonin uptake inhibitor. Prepn: A. A. Champseix et al., DE 2618152; eidem, US 4064255 (both 1977 to Mar-Pha Soc. Etud. Exploit. Marques). HPLC determn: C. Jozefczak et al., J. Chromatogr. 230, 87 (1982). Spectrofluorimetric determn and clinical pharmacology: A. Iliopoulou et al., Pharmatherapeutica 2, 613 (1981). Pharmacology: G. LeFur et al., Life Sci. 23, 1959 (1978); C. Gueremy et al., J. Med. Chem. 23, 1306 (1980); R. Ashkenazi et al., Br. J. Pharmacol. 79, 765, 915 (1983). Clinical study: A. Wauters, Acta Psychiatr. Belg. 83, 69 (1983).

Chemical structure

Derivative

Monohydrochloride.
C15H20N2.HCl; mol wt 264.79.
C 68.04%, H 7.99%, N 10.58%, Cl 13.39%.

Properties

mp 167°.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Bicyclics; Serotonin Uptake Inhibitor